AGO2 and melanoma: Moreover, a RIP assay was performed to validate the binding between circANKRD52 and Ago2‐miR‐141‐3p complex in melanoma cells, and we found that overexpression of circANKRD52 promoted the binding between circANKRD52 and Ago2 in the immunoprecipitates but silencing of circANKRD52 reduced their binding abilities (Figure 4G).