Herein, we identified a novel hsa_circ_0026926 derived from ANKRD52 and found circANKRD52 was upregulated in melanoma tissues and associated with the Breslow thickness, Clark levels, and poor prognosis in patients with melanoma, indicating that circANKRD52 might be a promising prognostic factor for melanoma patients. This evidence concerns the gene ANKRD52 and melanoma.