Importantly, broader cognitive involvement in HD has been associated with a worse prognosis, reflecting more widespread brain degeneration and potentially different coexisting pathological mechanisms, including tau-related pathology (Martinez-Horta et al., 2024, Martinez-Horta et al., 2020, Ruiz-Barrio et al., 2024, Vuono et al., 2015). The gene discussed is MAPT; the disease is Huntington disease.