Guideline-directed medical therapy and the 2022 American Heart Association/American College of Cardiology guidelines for HF includes diuretics for fluid management and core medications such as angiotensin receptor-neprilysin inhibitors, beta-blockers, mineralocorticoid receptor antagonists, and sodium-glucose cotransporter 2 inhibitors, all of which help improve symptoms, prevent disease progression, and reduce hospitalizations and mortality.54 This evidence concerns the gene SLC5A2 and hydrops fetalis.