The study results also revealed an increase in salivary TNF-α concentration in the untreated group compared to the therapeutically treated group, showing a beneficial role of maintenance therapy in balancing the periodontal and peri-implant clinical condition, which corroborated with our research when there was a transition of participants from mucositis group to control group after initial supportive therapy, during Time 2 (control= 18; mucositis=8), and at Time 3 (control=20; mucositis=6). The gene discussed is TNF; the disease is mucositis.