CD4 and anemia (phenotype): In another multicenter, double-blind, randomized controlled trial16 conducted in two hospitals in Malawi and South Africa, the use of LF-LAM in tuberculosis screening in HIV-positive inpatients did not reduce overall mortality in all patients, but it might have had benefits in some subgroups, such as those with low CD4 cell counts, those with severe anemia, or those with clinically suspected tuberculosis.