EIF4E and cyst: We recently reported a link between ORB2 and the testis-specific eIF4E paralog, eIF4E5, which is consistent with such a role (Shao et al. 2023): ORB2 and eIF4E5 genetically interact to control spermatid cyst polarization; additionally, eIF4E5 mutants display defects in SOTI protein accumulation and defective individualization, resulting in male sterility.