RAB5A and breast neoplasm: Histological analyses of breast tumors reveal that microinvasive regions, which are rich in motile cell markers such as Ras-related protein Rab-5A (RAB5A) and display elevated DNA damage [phosphorylated form of histone H2A variant X (γH2AX)], contain a high density of deformed nuclei, typically associated with cell crowding and migration (Fig. 5A, a and b) (158).