IFNA1 and viral infectious disease: Altogether, a fraction of LGP2 induction in viral infection is IFN- and cytokine-independent, highlighting exquisite gene expression control in antiviral innate immunity and representing an evolutionary advantage, which ensures uninterrupted supply of this RLR member protein in host responses to invading viruses in the event that IFN production and/or signalling is disabled by viral means.