Finally, to validate that human LGP2 promoter can be activated by virus infection in an IFN- and cytokine-independent manner in non-malignant cells, we performed dual luciferase reporter-based promoter activation assay in PH5CH8 cells, with and without pre-treatment of ruxolitinib, followed by mock-infection and SeV infection, respectively. Here, DHX58 is linked to viral infectious disease.