DHX58 and viral infectious disease: Among these, the retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) including RIG-I, melanoma differentiation-associated gene 5 (MDA5) and laboratory of genetics and physiology 2 (LGP2, a.k.a., DHX58) are key sensors of viral infections that engage viral RNAs in the cytoplasm [4, 5].