Genetic studies have also revealed links between LRRK2 mutations and sporadic cases of PD (Simón-Sánchez et al., 2009; Satake et al., 2009; Rocha et al., 2022), and increased kinase activity in an otherwise wild-type LRRK2 in postmortem samples from idiopathic PD patients has also been reported (Di Maio et al., 2018). Here, LRRK2 is linked to Parkinson disease.