N551K was reported to confer protection to both PD and Crohn’s disease (Hui et al., 2018; Kalogeropulou et al., 2022), and an overexpression study showed a mild but statistically significant negative impact of N551K on MLi-2-induced association between LRRK2 and microtubules (Kalogeropulou et al., 2022). This evidence concerns the gene LRRK2 and Crohn disease.