LRRK2 and Parkinson disease: To determine whether the autoinhibited form of LRRK2 can bind to and oligomerize on microtubules, we used cryo-electron tomography (cryo-ET) to image purified full-length LRRK2 (LRRK2WT) and one of its hyperactive PD-linked mutants (LRRK2I2020T) reconstituted with microtubules, either in the absence or presence of type-I (MLi-2) or type-II (GZD-824) LRRK2 inhibitors.