HIF1A and neoplasm: Furthermore, H. pylori-induced immune responses and the hypoxic conditions within the tumor niche activate HIF-1α, which collaborates with BRD4 to upregulate glycolysis-related genes such as Slc2a1 (Solute Carrier Family 2 Member 1) and Hk2 (hexokinase 2) [54] (Fig. 1).