In addition, serum PlGF concentrations were elevated in patients with advanced MF/SS and showed a positive correlation with key disease biomarkers, including not only Ang-2, but also CCL27, a chemokine involved in T cell skin homing and interleukin-10 (IL-10), an immunosuppressive cytokine known to contribute to tumor immune evasion. This evidence concerns the gene IL10 and neoplasm.