Notably, miR‐140‐5p directly targets the mRNAs of NRF2 and SIRT2, two key regulators of the antioxidant defense system, thereby increasing oxidative stress (Liu et al. 2019), which is a hallmark of aging (López‐Otín et al. 2023), and a central factor in the HGPS pathogenesis (Cau et al. 2014). This evidence concerns the gene NFE2L2 and Hutchinson-Gilford progeria syndrome.