As demonstrated by Kubben et al. (2016), NRF2 knockdown in wild‐type fibroblasts or mesenchymal stem cells derived from genetically corrected HGPS iPSCs (GC‐iPSC‐MSCs) mimics several HGPS defects even if the toxic progerin protein is absent, including increased ROS levels and reduced antioxidant gene expression. Here, NFE2L2 is linked to Hutchinson-Gilford progeria syndrome.