Mitochondrial dysfunction is a well‐established feature of HGPS, characterized by aberrant morphology, reduced mobility, decreased ATP production, and impaired mitogenesis due to decreased peroxisome proliferator‐activated receptor‐gamma coactivator‐1 alpha (PGC‐1α) expression (Mateos et al. 2015; Xiong et al. 2016; Kang et al. 2017). The gene discussed is PPARGC1A; the disease is Hutchinson-Gilford progeria syndrome.