As demonstrated by Kubben et al. (2016), NRF2 knockdown in wild‐type fibroblasts or mesenchymal stem cells derived from genetically corrected HGPS iPSCs (GC‐iPSC‐MSCs) mimics several HGPS defects even if the toxic progerin protein is absent, including increased ROS levels and reduced antioxidant gene expression. This evidence concerns the gene LMNA and Hutchinson-Gilford progeria syndrome.