For example, 1 male infant diagnosed with JXG at 3 months later developed JMML, and sequencing revealed the same p.E76K PTPN11 mutation in both diseases.42 A hotspot PTPN11 p.E76V mutation was also detected in Patient 2, who has not exhibited signs of JMML. The gene discussed is PTPN11; the disease is juvenile xanthogranuloma.