In evaluating inflammatory response indicators between patients with high platelet count and low platelet count undergoing lung cancer surgery, on the day before surgery, no significant differences were found in IL-6 (2.65 ± 0.93 vs. 2.79 ± 0.82, 1.142, p = 0.255), IL-10 (1.39 ± 0.53 vs. 1.47 ± 0.59, 0.907, p = 0.366), TNF-α (1.59 ± 0.64 vs. 1.64 ± 0.67, 0.572, p = 0.568), and WBC (7.38 ± 1.62 vs. 7.26 ± 1.67, 0.525, p = 0.6). This evidence concerns the gene TNF and lung cancer.