In the fully adjusted model (Model 3: age, sex, race, BMI, waist circumference, physical activity, drinking, smoking, diabetes, hypertension, hyperlipidemia, CVD, ALT, and AST), each 1-unit increase in the continuous SDoH score conferred a 15% higher risk of all-cause mortality (HR = 1.15, 95% CI: 1.11–1.191) and a 13% increased risk of cardiovascular mortality (HR = 1.13, 95% CI: 1.06–1.21). The gene discussed is GPT; the disease is Hypertension.