For example, a case report of a 73-year-old male with gastric SMARCA4-deficient high-grade sarcomatoid carcinoma showed that the patient was unresponsive to chemotherapy (11); however, a case report of a 59-year-old male with gastric SMARCA4-deficient sarcoma demonstrated that the patient had a good response to combined chemotherapy with doxorubicin and ifosfamide after surgery and remained alive during 49 months of follow-up (18). This evidence concerns the gene SMARCA4 and sarcoma.