Compared to normal blood samples from the GTEx database, the mRNA expression of the SIRT family was dysregulated in ALL samples from the TARGET database when the mRNA expression of SIRT1, SIRT3, SIRT4, SIRT5, and SIRT6 was significantly increased, and the mRNA expression of SIRT2 and SIRT7 was decreased (Supplementary Figure S1A). The gene discussed is SIRT6; the disease is acute lymphoblastic leukemia.