The K-M survival curves revealed that the higher mRNA expression of SIRT1, SIRT4, SIRT5, or SIRT7 has a longer event-free survival time in ALL, but the event-free survival time was shorter in ALL with the higher mRNA expression of SIRT2 (p < 0.05) (Supplementary Figures S2A-G). Here, SIRT4 is linked to acute lymphoblastic leukemia.