MAPT and Alzheimer disease: Neuropathologically, AD is defined by the accumulation of extracellular β-amyloid (Aβ) plaques, the formation of neurofibrillary tangles composed of hyperphosphorylated Tau protein, and subsequent synaptic dysfunction and neuronal loss (Pritchard et al., 2017; Jungbauer et al., 2022; Li et al., 2022; Mao et al., 2022; Weber et al., 2023; Wereszczyński et al., 2023; Zhao et al., 2023).