While FnBPs exhibit negligible direct arthritogenicity, they drive interleukin-6 (IL-6)-dominated cytokine storms via integrin α5β1/fibronectin bridging, thereby inducing weight loss, increased mortality, and bacteremia in murine sepsis models (Palmqvist et al., 2005; Speziale and Pietrocola, 2020). Here, IL6 is linked to Sepsis.