CD274 and melanoma: Among cuproptosis-related genes (CRGs), LIPT1 is identified as an independent prognostic factor, positively correlating with PD-L1 expression while negatively regulating Treg cell infiltration (Lv et al., 2022); PPIC is a promoter of melanoma progression, enhancing cell invasiveness while suppressing CD8+T cell activation (Zhou et al., 2024).