CD8+ T cells play a crucial role in triggering ferroptosis in cancer cells: IFNγ produced by CD8+ T cells suppresses the Xc− system and upregulates ACSL4 expression, promoting ferroptosis in tumor cells (Dixon et al., 2012; Wang et al., 2019; Liao et al., 2022). The gene discussed is CD8A; the disease is neoplasm.