To investigate this hypothesis, we employed the Grx2-knockout mouse model, and the ShipΔB mouse model, a B cell-specific Src homology 2-containing inositol 5-phosphatase 1 (SHIP-1) knockout strain that develops spontaneous SLE-like autoimmunity (O'Neill et al., 2011; Zhang H. et al., 2019). Here, GLRX2 is linked to Autoimmunity.