GLRX2 and cancer: This mechanism mirrors Grx2’s role in mitigating age-related pathologies, such as cancer incidence (Brzozowa-Zasada et al., 2024), cataract formation (Wu et al., 2014), or neurodegeneration (Wen et al., 2020), where Grx2’s deficiency accelerates oxidative damage or cell remodeling that may result in abnormal activation or carcinogenesis.