The overexpression or amplification of the MDM2 oncogene is a recurrent event across a broad spectrum of human cancers, including carcinomas of the lung, breast, liver, and gastrointestinal tract, as well as a defining feature of malignancies like well-differentiated and dedifferentiated liposarcoma (Wade et al., 2013; Wang W. et al., 2024). The gene discussed is MDM2; the disease is liposarcoma.