PPARA and diabetic kidney disease: Notably, Boeravinone C, a novel natural monomer isolated from O. himalaicus, showed bidirectional regulation in DKD mice models and human renal tubular epithelial cells (HK-2) experiments: On the one hand, it activates PPARα transcription factor, enhances FAO ability, and reduces renal tubular lipid accumulation; on the other hand, it inhibits the NF-κB inflammatory pathway and reduces the inflammatory response.