Naringenin can directly up-regulate PPARα/PPARγ protein expression through activation of the CYP4A-20-HETE pathway, and at the same time inhibit the activity of pro-fibrotic factors, such as transforming growth factor-β (TGF-β), and interleukin-1 (IL-1), and ultimately improve the state of lipid metabolism disorders (75). The gene discussed is PPARG; the disease is Disorder of lipid metabolism.