Functional enrichment analysis mapped these differentially expressed miRNAs to critical oncogenic signaling cascades (including the Ras/MAPK signaling pathway), immune regulation (the Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, and TNF signaling pathway), and immune-metabolic processes such as lipid metabolism and atherosclerosis regulation (Figure 2f). The gene discussed is TNF; the disease is atherosclerosis.