DEG - differentially expressed gene; CRC - colorectal cancer; KRAS - Kirsten rat sarcoma virus; APC - adenomatous polyposis coli; IBD - inflammatory bowel syndrome; AOM - azoxymethane; DSS - dextran sodium sulfate; PDO - patient-derived organoids; PDOX - PDO-derived xenograft; T2DM - type 2 diabetes mellitus. The gene discussed is APC; the disease is inflammatory bowel disease.