WBC: white blood cells; RBC: red blood cells; HCT: hematocrit; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; RDW-CV: red cell distribution width-coefficient of variation; AGAP: anion gap; NT-proBNP: N-terminal pro-B-type natriuretic peptide; eGFR: estimated glomerular filtration rate; CKD-EPI: chronic kidney disease epidemiology collaboration equation. The gene discussed is NPPB; the disease is chronic kidney disease.