NFKB1 and psoriasis: NF-κB is an essential nuclear transcription factor in immune cell and keratinocyte biology and plays an important role in the inflammation (14) It has been demonstrated NF-κB translocation in lymphocytes within psoriatic skin triggers its subsequent translocation in the epidermis and basal cells which is responsible for two of the main features of psoriasis, epidermal hyperplasia, and inflammation (15) In addition, the activation of NF-κB signaling by inducing the expression of keratins 6 and 16 in keratinocytes, can lead to acanthosis and decreased turnover time in the epidermis (16).