Furthermore, topical application of IMQ has been found to persuade a dermatitis in mice thoroughly like human psoriasis (19) IMQ can activate the production of downstream factors such as TNF -α, IL -1β, IL -6, and IL -23 by binding with epidermal plasma -like dendritic cells and Toll -like receptor (TLR) -7 in macrophages, mimicking inflammatory changes in psoriasis (20). Here, TNF is linked to psoriasis.