SYR was detected in the serum of PRS, H-ECs, and isolated aortic rings, indicating CPSDS endothelium-dependent vasodilation production of NO, mediated antioxidation-sensitive function of Src kinase, leading to consequential PI3/Akt-mediated phosphorylation of EnosAnti-atherosclerosis efficacy. The gene discussed is WNK3; the disease is atherosclerosis.