↑ Bcl-2, p-Akt, p-PI3K, p-GSK-3β, and mitochondria cytochrome c levels↓ Caspase-3, -9, and Bax expressionsProtection of myocardial systolic (LVEF and LVFS)↓ CK-MB and LDH levels in serum↓ Index of apoptosisSuppression of mitochondria-induced apoptosis Modulating by the PI3K/Akt/GSK-3β pathwayRelieved myocardial ischemia/reperfusion injury. Here, CYCS is linked to myocardial ischemia.