The mean WOMAC Indexscore was also higher in patients with vitamin - D deficiency (20 ng/ml and lower); with the highest mean score of 81.39±6.84.The study highlights the importance of maintaining adequate vitamin - D levels in patients with knee osteoarthritis (Table 4 - see PDF).It was observed that as KL grades increase the level of vitamin - D decreases and there was a statistically significant strongassociation between serum vitamin - D levels and IL-6 concentrations in patients with knee osteoarthritis (p<0.05)(Table 5, 6 - see PDF). The gene discussed is IL6; the disease is vitamin D deficiency.