In this regard, a recent meta-analysis of 42 random clinical trials (RCTs) utilizing nutraceuticals(such as chondroitin sulphate, glucosamine sulphate, collagen, and hyaluronic acid) found improvements across all OA measurementparameters expressed through the total WOMAC index, WOMAC pain and WOMAC stiffness subscales, and VAS [13].Therefore, it is of interest to explore the correlation between serum vitamin - D levels and cytokine profiles (IL-6 and TNF ALPHA) inpatients with knee osteoarthritis, using clinical assessment with the WOMAC score. The gene discussed is TNF; the disease is osteoarthritis, knee.