Insulin is critical for glucose metabolism, and its dysregulation can significantly impact weight [27].In postmenopausal women, declining estrogen levels are associated with increased insulin resistance, which can exacerbate weight gain.Hyperinsulinemia, or elevated insulin levels, promotes fat storage, and inhibits lipolysis (the breakdown of fat), contributing todifficulty in weight management [28]. This evidence concerns the gene INS and Insulin resistance.