Concurrently, hypoestrogenism also partially triggers a notable decrease in growth hormone (GH), which increases thetendency to accumulate abdominal fat and reduces lipid metabolism (Figure 4 - see PDF) [30].Studies suggest that transdermal estrogen therapy improves glucose homeostasis and reduces the risk of type 2 diabetes in postmenopausalwomen. This evidence concerns the gene GH1 and type 2 diabetes mellitus.