The inverse relationship between SOD and MDA in our cohort directly links antioxidant depletion to oxidative damage, reinforcing SOD’s role as a critical gatekeeper—a mechanism supported by Li et al., who showed that SOD2 mitigates noise-induced hearing loss in mice, but here contextualized in a human occupational setting (Li et al., 2020). The gene discussed is SOD1; the disease is hearing loss disorder.