SLC6A8 and Intellectual disability: Finally, mice lacking the creatine transporter Slc6a8 (3-fold enriched in our dataset) selectively in PV interneurons recapitulated numerous features of the Creatine Transporter Deficiency (CTD), an X-linked neurometabolic disorder presenting with intellectual disability, autistic-like features, and epilepsy (Ghirardini et al., 2023).