Thus, motor symptoms associated to GRIN2D-and SLC6A1-related disorders including dystonia, chorea and hyperactivity and tremor among others (Cha et al., 2025; Chiu et al., 2005; Gawande et al., 2023; Goodspeed et al., 2020, 1993; Vinnakota et al., 2023), could result from dysfunction of these genes encoding the glutamate ionotropic receptor NMDA subunit 2D (Grin2d) and the GABA transporter (Slc6a1) respectively, which are both highly enriched in DS PV interneurons. The gene discussed is GRIN2D; the disease is choreatic disease.