LGALS3 and early-onset autosomal dominant Alzheimer disease: Previous studies demonstrated that GAL3 is upregulated in various human conditions such as Alzheimer’s disease and stroke (Al-Dalahmah et al., 2020; Tan et al., 2021), as well as in rodent models including Alzheimer’s disease, multiple sclerosis, stroke, and hypoxia/ischemia (Akazawa et al., 2004; Boza-Serrano et al., 2019; Walther et al., 2000; Young et al., 2014).