,2 During endotoxemia, immune cells recognize LPS through the Toll-like receptor 4 (TLR4)/MD2 complex, resulting in the activation of the NF-κB signaling pathway and the production of proinflammatory cytokines and free radicals, such as ROS and RNS.9 The gene discussed is NFKB1; the disease is serum lipopolysaccharide activity.