These tumor-associated MSCs differentiate into cancer-associated fibroblasts (CAFs), which secrete pro-angiogenic and immunosuppressive factors, including PDGF, FGF, VEGF, IL-6, and IL-8, that promote cancer cell survival, angiogenesis, immunosuppression, tumor growth, and metastasis (111). This evidence concerns the gene CXCL8 and neoplasm.