NLRP3 and obesity due to melanocortin 4 receptor deficiency: Notably, the liver is one of the primary organs involved in obesity‐related inflammation, while the proinflammatory cytokine IL‐1β contributes to the pathogenesis of MS through activating the NLRP3 inflammasome; in this process, the inflammasome facilitates the release of additional proinflammatory cytokines that exacerbate hepatic insulin resistance and dysregulated lipid metabolism (Esser et al. 2014).