Notably, the liver is one of the primary organs involved in obesity‐related inflammation, while the proinflammatory cytokine IL‐1β contributes to the pathogenesis of MS through activating the NLRP3 inflammasome; in this process, the inflammasome facilitates the release of additional proinflammatory cytokines that exacerbate hepatic insulin resistance and dysregulated lipid metabolism (Esser et al. 2014). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.