Further supporting this mechanism, a pericentric inversion (chr7: 29,043,157–96,185,954) displaced DYNC1I1 exons 15 and 17 nearly 67 Mb away from DLX5/6, preventing proper enhancer-promoter interactions and leading to SHFM1 and hearing loss (Birnbaum et al., 2012b). The gene discussed is DYNC1I1; the disease is hearing loss disorder.