Interestingly, BMP4 was also upregulated in tumor vasculature, implying potential secretion, although proteomic datasets (the PXD009139 cohort deposited in the Proteomics Identifications Database (PRIDE) and the IPX0001579000 cohort deposited in the Integrated Proteome Resources database (iProX)) did not detect BMP4 in serum. This evidence concerns the gene BMP4 and neoplasm.