BMP4 and lung adenocarcinoma: We determined the relative methylation levels of BMP4 locus in various cancer types and found that its methylation was relatively low in testicular cancer (TGCT), PCPG, and mesothelioma (MESO) but relatively high in thyroid cancer (THCA), PAAD, and lung adenocarcinoma (LUAD) (Supplementary Figure S2A).