TARDBP and amyotrophic lateral sclerosis: This article first presented case summaries of three ALS patients: two families with TARDBP p.G298S presenting with heterogeneous clinical phenotypes, including a case with an unusual extraocular muscle onset. A review of TARDBP p.G298S cases reported worldwide was conducted, surveying the age and site of onset, disease duration, and motor neuron involvement. Finally, an overview of genetic mutations reported locally for ALS was presented, showing that TARDBP p.G298S is a common mutation detected in this locality.