TARDBP and respiratory failure: A summary of all cases (n=40) with the TARDBP p.G298S mutation reported globally shows it is primarily found in Eastern Asia among the ethnic Chinese and Japanese populations, with one case in a Caucasian patient in the U.S. (Table 3) [1,5,8-14]. The mutation was first reported in a Chinese family in the U.S. in 2008, where all five patients quickly progressed to quadriparesis and respiratory failure within one to four years, regardless of onset type [9].