SHBG and gastric cancer: This finding is consistent with the results of two prospective studies based on the UK Biobank, which reported that elevated SHBG levels were associated with an increased risk of GC.[23,41] Another meta-analysis also showed that higher levels of SHBG increased the risk of GC in men.[42] Our study provides novel epidemiological evidence supporting the hypothesis that sex hormone dysregulation may play a role in gastric carcinogenesis.