It may interact with Netrin-1 to enhance overall HCC cell migration.[38] In HCC, increased extracellular matrix stiffness upregulates plectin expression, increasing F-actin polymerization to promote cell migration.[39] Although both DSP and plectin can affect cell migration, plectin has been shown to be potentially associated with the collective migration of cells. This evidence concerns the gene PLEC and hepatocellular carcinoma.