It may interact with Netrin-1 to enhance overall HCC cell migration.[38] In HCC, increased extracellular matrix stiffness upregulates plectin expression, increasing F-actin polymerization to promote cell migration.[39] Although both DSP and plectin can affect cell migration, plectin has been shown to be potentially associated with the collective migration of cells. The gene discussed is NTN1; the disease is hepatocellular carcinoma.