MACF1 and colorectal carcinoma: For example, lipoprotein receptor-related protein 6 (LRP6) regulates microtubules (MT) assembly in CRC cells via MACF1, thereby influencing cytoskeletal remodeling, and its overexpression promotes CRC cell migration.[21] Additionally, plectin can function downstream of transcobalamin 1 (TCN1) in CRC, and its degradation compromises the stability of filamin A and F-actin networks, leading to cytoskeletal damage and CRC cell migration.[22] Furthermore, plectin influences podosomelike adhesion.