However, no plectin-positive circulating tumor cells were detected in samples from healthy individuals.[64] Nevertheless, its comparison with immunofluorescence-fluorescence in situ hybridization remains to be explored.[65] These findings suggest that plectin is a reliable marker for the diagnosis of PC; however, large multicenter randomized controlled studies are required to confirm these findings. The gene discussed is PLEC; the disease is pachyonychia congenita.