Transferrin receptor protein 1 gene knockout-induced anemia triggers lethal cardiomyopathy due to cardiomyocyte metabolic dysfunction, characterized by impaired oxidative phosphorylation and defective mitophagy.[2] Prior studies have also shown that anemia increases all-cause and cardiovascular mortality in AF patients, and reduces post-ablation sinus rhythm maintenance rates. The gene discussed is TFRC; the disease is anemia (phenotype).