Bioinformatics analysis of effective biomarkers in type 2 diabetes with cognitive impairment and aging indicates that the genes TP53 and IL1B may play a potential role in influencing the progression of type 2 diabetes associated with cognitive impairment and aging through the Lipid and atherosclerosis, MAPK signaling, and fluid shear stress and atherosclerosis signaling pathways (72). Here, TP53 is linked to type 2 diabetes mellitus.