In the core-binding factor acute myeloid leukemia with t(8;21) or inv(16) fusions, transcriptional repression of ADAR2 by runt-related transcription factor 1 (RUNX1-ETO) reduces editing of key targets, coatomer protein complex subunit alpha (COPA), and component of oligomeric Golgi complex 3 (COG3). The gene discussed is RUNX1; the disease is acute myeloid leukemia.