ADAR1 also influences circRNA biogenesis by editing Alu-paired sequences, suppressing tumor-suppressive circRNA ARSP91 (circARSP91) in HCC, while certain circRNAs such as circRNA derived from the NEIL3 gene (circNEIL3) provide feedback to regulate ADAR1 expression (89–91). The gene discussed is ADAR; the disease is hepatocellular carcinoma.