In glioblastoma multiforme, low ADAR2 protein levels correlate with poorer overall survival, and suppression of ADAR2 enhances proliferation, migration, and anchorage-independent growth, and upregulates invasion-associated genes, e.g., a disintegrin and metalloproteinase domain-containing protein 12 (ADAM12), pentraxin 3, and EMT pathway genes (92). This evidence concerns the gene ADARB1 and glioblastoma.