Low-density lipoprotein receptor-related protein 1 (LRP1) is an endocytosed transmembrane receptor involved in a variety of biological pathways, which not only serves as a signaling receptor, but also has a variety of functions such as ligand endocytosis, inhibition of cancer cell growth and metastasis, and regulation of the diffusion of microtubule-associated proteins in the brain (29, 30). Here, LRP1 is linked to cancer.