The results demonstrated that the nomogram model, incorporating norepinephrine, normetanephrine, metanephrine, serum uric acid, serum creatinine, hypertension duration, and cystatin C, achieved C-indices of 0.834 and 0.823 in the training and validation sets, respectively, with AUC values exceeding 0.8 and satisfactory sensitivity and specificity. The gene discussed is CST3; the disease is hypertensive disorder.