In a murine model of aristolochic acid-induced AKI (AAI-AKI), downregulation of proline-serine-threonine phosphatase-interacting protein 2 (PSTPIP2) was identified as the critical step mediating RTEC injury and apoptosis while promoting neutrophil infiltration (107). The gene discussed is PSTPIP2; the disease is acute kidney injury.