S100A8 and acute kidney injury: For instance, our previous research in ischemia-reperfusion injury induced AKI (IRI-AKI) models revealed that neutrophils highly express myeloid-related proteins MRP8/S100A8 and MRP14/S100A9, which further promote TEM of phagocytes (including neutrophils) by regulating cytoskeletal metabolism via microtubule reorganization (22, 23).