TLR3 and Familial prostate cancer: 1. Trigger TLR3-induced autophagy in cancer cells, activating NF-κB and MAPK pathways and enhancing migration and invasion, autophagy induces CCL20 release;2. CCL20 can recruit macrophages into the tumor microenvironment (TME) and polarizes them toward pro-tumor M2 Macrophages, further enhancing prostate cancer invasiveness.