CD8A and colorectal cancer: 1. Activate CD8+ T cells to produce IFN-γ and granzyme and further up-regulates tumor MHC I expression to reinforce immune responses;2. Activate the cGAS/STING pathway by inhibiting histone deacetylases (HDACs) to induce DNA damage in colorectal cancer cells, up-regulating chemokines (CCL5, CXCL10) and ISGs