ACKR3 and neoplasm: While our Western blot experiments have confirmed the functional role of the TGF-β pathway in response to genetic manipulations of CXCR7 and TAGLN2 in cell lines, comprehensive in vivo studies, such as xenograft or metastasis models, are essential to elucidate how this axis impacts tumor growth, invasion, and metastatic potential within a complex biological microenvironment.