TAGLN2 and metastatic malignant neoplasm in the lymph nodes: Furthermore, elevated expression levels of CXCR7 and TAGLN2 were significantly associated with lymph node metastasis in PTC patients (CXCR7, p < 0.05; TAGLN2, p < 0.05; R = 0.353), providing strong evidence for their involvement in PTC progression.