The genes associated with human AIP include the HLA alleles DRB1∗16 and HLA-DQB1∗05 (6), FCRL3 (7), CTLA-4 (8, 9), KCNA3 (10), and specific PRSS1 mutations (PRSS1_IVS 2 + 56_60 delCCCAG and PRSS1_p.Leu81Met) that were suggested to cause ectopic trypsinogen activation (11, 12). The gene discussed is PRSS1; the disease is autoimmune pancreatitis.